He will take over from Matt Waddell, who retired last month after spending 35 years with the group.
Jukes brings over 25 years corporate finance experience with him, having advised private businesses, corporates and private equity clients on a broad range of transactions from finance raising through to divestments.
He began his career with the firm in 1992, where he was involved in a wide range of transactions, many involving private, entrepreneurial businesses in the region.
Alongside his corporate finance role, Jukes is the independent senior partner to a number of clients where he acts as a board level advisor on a broad range of topics from organisational change and transformation through to portfolio reviews and M&A strategies.
He said: “I’m delighted to take on this role and return to the Midlands to build on the existing momentum our corporate finance business has built within the region.
“I am particularly proud of the work we have been doing with our clients during such a challenging time, which continues to have a significant impact on businesses and the local economy.”
Matthew Hammond, Midlands region leader and Birmingham senior partner, PwC, added: “Darren has extensive experience of managing large corporate finance deals, organisational change and transformation. Darren has successfully led a wide range of Deals and other advisory work for our clients which will help grow our corporate finance business further.”